TY  - CHAP
M1  - Book, Section
TI  - Depression and Gynecologic Conditions
A1  - Miller, Laura
A1  - Athappilly, Geena
A1  - Avni-Barron, Orit
A1  - Carusi, Daniela
A1  - Joffe, Hadine
A2  - Barsky, Arthur J.
A2  - Silbersweig, David A.
A2  - Boland, Robert J.
PY  - 2016
T2  - Depression in Medical Illness
AB  - Depression  is  more  common  in  women  than  in  men  during  the  reproductive  years,  particularly  in  association  with  reproductive  transitions  and  several  common  gynecological  conditions.  In  the  first  part  of  this  chapter,  we  review  specific  evidence  supporting  an  association  of  mood  disturbance  with  puberty  in  girls,  across  the  menstrual  cycle,  with  polycystic  ovary  syndrome,  with  infertility,  and  during  the  transition  to  menopause.  Because  of  the  prevalence  of  depression  in  women  during  the  reproductive  years,  there  are  some  important  implications  for  pharmacologic  treatment.  Some  psychotropic  medications  can  have  adverse  effects  on  the  hypothalamic–pituitary–gonadal  (HPG)  axis,  which  manifest  in  menstrual  dysfunction,  as  well  as  potentially  disruptive  interactions  with  both  endogenous  and  exogenous  reproductive  hormones.  In  the  second  part  of  this  chapter,  we  review  what  is  known  about  the  effect  of  psychotropic  medications  on  the  HPG  axis,  and  discuss  important  interactions  with  reproductive  hormones.  Given  that  women  of  reproductive  age  comprise  a  large  proportion  of  psychiatric  patients,  knowledge  about  these  special  considerations  will  improve  treatment  outcomes  for  a  large  number  of  women.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - neurology.mhmedical.com/content.aspx?aid=1138125343
ER  -