TY - CHAP M1 - Book, Section TI - PARKINSON’S DISEASE AND OTHER MOVEMENT DISORDERS A1 - Olanow, C. Warren A1 - Schapira, Anthony H.V. A1 - Obeso, Jose A. A2 - Hauser, Stephen L. A2 - Josephson, S. Andrew Y1 - 2018 N1 - T2 - Harrison's Neurology in Clinical Medicine, 4e AB - Parkinson’s disease (PD) is the second commonest neurodegenerative disease, exceeded only by Alzheimer’s disease (AD). Its cardinal clinical features were first described by the English physician James Parkinson in 1817. It is noteworthy that James Parkinson was a general physician who captured the essence of this condition based on a visual inspection of a mere handful of patients. It is estimated that approximately 1 million persons in the United States, 1 million in Western Europe, and 5 million worldwide suffer from this disorder. PD affects men and women of all races, all occupations, and all countries. The mean age of onset is about 60 years. The frequency of PD increases with aging, but cases can be seen in patients in their 20s and even younger. Based on the aging of the population and projected demographics, it is estimated that the prevalence of the disease will dramatically increase in the next several decades. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - neurology.mhmedical.com/content.aspx?aid=1145769683 ER -