RT Book, Section A1 Robinson, Christopher A1 Wijdicks, Eelco A2 Salardini, Arash A2 Biller, José SR Print(0) ID 1127047226 T1 Coma and Other States of Altered Consciousness T2 The Hospital Neurology Book YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071845830 LK neurology.mhmedical.com/content.aspx?aid=1127047226 RD 2024/04/25 AB Abnormal consciousness is caused by pathologies that specifically alter the function of a neuronal network responsible for causing awareness and alertness. Understanding of the basic concepts of this arousal system and the pathophysiologic mechanisms underlying its alteration are imperative in the diagnosis, treatment, and long-term management of coma. This chapter will focus on the definition of consciousness, the physiology of arousal, the pathologies underlying coma, the neurologic examination of the comatose patient, management of coma, and assessment of prognosis. Each section is accompanied by a case to illustrate the different clinical scenarios in which coma can present.