RT Book, Section
A1 Safar, Laura
A1 Sullivan, John
A1 Baslet, Gaston
A1 Harder, Jessica
A1 Morrissey, Laura
A1 Raj, Shreya
A1 Daffner, Kirk
A1 Silbersweig, David
A2 Barsky, Arthur J.
A2 Silbersweig, David A.
A2 Boland, Robert J.
SR Print(0)
ID 1138124892
T1 Depression and Neurologic Illness
T2 Depression in Medical Illness
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071819084
LK neurology.mhmedical.com/content.aspx?aid=1138124892
RD 2024/04/24
AB Depression  is  the  most  highly  prevalent  neuropsychiatric  syndrome  across  all  neurologic  illnesses  (Fig.  5-1).  The  relationship  between  depression  and  neurologic  illness  is  complex  in  several  aspects,  including  pathophysiology,  clinical  presentation,  and  response  to  treatment.  Depression  may  sometimes  be  the  direct  result  of  brain  pathology,  very  much  like  other  neurological  manifestations,  such  as  cognitive  or  motor  disturbances.  In  other  cases,  a  more  complex  interplay  of  neurobiological,  environmental,  and  coping  mechanisms  appears  responsible  for  the  development  of  depressive  symptoms  (Box  5-1).  Neurologic  illness  may  produce  signs  and  symptoms  that  mimic  depression,  such  as  psychomotor  retardation,  apathy,  concentration  deficits,  and  sleep  disorders,  making  the  diagnosis  of  depression  in  the  context  of  neurologic  illness  challenging.  However,  the  identification  and  treatment  of  depression  in  these  individuals  is  of  fundamental  importance,  as  this  tends  to  improve  the  prognosis  of  the  neurological  disease.