RT Book, Section
A1 Mesulam, M.-Marsel
A2 Hauser, Stephen L.
A2 Josephson, S. Andrew
SR Print(0)
ID 1145768254
T1 APHASIA, MEMORY LOSS, AND OTHER FOCAL CEREBRAL DISORDERS
T2 Harrison's Neurology in Clinical Medicine, 4e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259835865
LK neurology.mhmedical.com/content.aspx?aid=1145768254
RD 2024/04/24
AB The  cerebral  cortex  of  the  human  brain  contains  approximately  20  billion  neurons  spread  over  an  area  of  2.5  m2.  The  primary  sensory  and  motor  areas  constitute  10%  of  the  cerebral  cortex.  The  rest  is  subsumed  by  modality-selective,  heteromodal,  paralimbic,  and  limbic  areas  collectively  known  as  the  association  cortex(Fig.  22-1).  The  association  cortex  mediates  the  integrative  processes  that  subserve  cognition,  emotion,  and  comportment.  A  systematic  testing  of  these  mental  functions  is  necessary  for  the  effective  clinical  assessment  of  the  association  cortex  and  its  diseases.  According  to  current  thinking,  there  are  no  centers  for  “hearing  words,”  “perceiving  space,”  or  “storing  memories.”  Cognitive  and  behavioral  functions  (domains)  are  coordinated  by  intersecting  large-scale  neural  networks  that  contain  interconnected  cortical  and  subcortical  components.  Five  anatomically  defined  large-scale  networks  are  most  relevant  to  clinical  practice:  (1)  a  perisylvian  network  for  language,  (2)  a  parietofrontal  network  for  spatial  orientation,  (3)  an  occipitotemporal  network  for  face  and  object  recognition,  (4)  a  limbic  network  for  retentive  memory,  and  (5)  a  prefrontal  network  for  the  executive  control  of  cognition  and  comportment.