RT Book, Section
SR Print(0)
ID 1101682192
T1 Genetic Mechanisms in Degenerative Diseases of the Nervous System
T2 Principles of Neural Science, Fifth Edition
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-139011-8
LK neurology.mhmedical.com/content.aspx?aid=1101682192
RD 2024/04/19
AB Expanded  Trinucleotide  Repeats  Characterize  Several  Neurodegenerative  DiseasesHuntington  Disease  Involves  Degeneration  of  the  StriatumSpinobulbar  Muscular  Atrophy  Is  Due  to  Abnormal  Function  of  the  Androgen  ReceptorHereditary  Spinocerebellar  Ataxias  Include  Several  Diseases  with  Similar  Symptoms  but  Distinct  EtiologiesParkinson  Disease  Is  a  Common  Degenerative  Disorder  of  the  ElderlySelective  Neuronal  Loss  Occurs  After  Damage  to  Ubiquitously  Expressed  GenesAnimal  Models  Are  Powerful  Tools  for  Studying  Neurodegenerative  DiseasesMouse  Models  Reproduce  Many  Features  of  Neurodegenerative  DiseasesInvertebrate  Models  Manifest  Progressive  NeurodegenerationSeveral  Pathways  Underlie  the  Pathogenesis  of  Neurodegenerative  DiseasesProtein  Misfolding  and  Degradation  Contribute  to  Parkinson  DiseaseProtein  Misfolding  Triggers  Pathological  Alterations  in  Gene  ExpressionMitochondrial  Dysfunction  Exacerbates  Neurodegenerative  DiseaseApoptosis  and  Caspase  Modify  the  Severity  of  NeurodegenerationAdvances  in  Understanding  the  Molecular  Basis  of  Neurodegenerative  Diseases  Are  Opening  Possibilities  for  Approaches  to  Therapeutic  InterventionAn  Overall  View