Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Lennon J, Shah R. Lennon J, & Shah R Lennon, Jack, and Ravi Shah. Febuxostat not effective at delaying progression of carotid atherosclerosis in asymptomatic hyperuricemia. 2 Minute Medicine, 15 May 2020. McGraw-Hill, 2020. AccessNeurology. https://neurology.mhmedical.com/updatesContent.aspx?gbosid=550136§ionid=247076620APA Citation Lennon J, Shah R. Lennon J, & Shah R Lennon, Jack, and Ravi Shah. (2020). Febuxostat not effective at delaying progression of carotid atherosclerosis in asymptomatic hyperuricemia. (2020). 2 minute medicine. McGraw-Hill. https://neurology.mhmedical.com/updatesContent.aspx?gbosid=550136§ionid=247076620.MLA Citation Lennon J, Shah R. Lennon J, & Shah R Lennon, Jack, and Ravi Shah. "Febuxostat not effective at delaying progression of carotid atherosclerosis in asymptomatic hyperuricemia." 2 Minute Medicine McGraw-Hill, 2020, https://neurology.mhmedical.com/updatesContent.aspx?gbosid=550136§ionid=247076620. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Clip Full Chapter Figures Only Tables Only Videos Only Supplementary Content Top Febuxostat not effective at delaying progression of carotid atherosclerosis in asymptomatic hyperuricemia by Jack Lennon, Ravi Shah Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. While there was no placebo control group, treatment with febuxostat for 24 months did not slow carotid atherosclerosis progression in Japanese individuals with asymptomatic hyperuricemia. +Evidence Rating Level: 2 (Good) +Allopurinol, a purine analogue xanthine oxidase (XO) inhibitor, is a conventional pharmacological intervention for reducing serum uric acid (SUA) levels, which increases risk of cardiovascular disease. Febuxostat, a novel non-purine selective inhibitor of XO, has been found to have greater efficacy in lowering urate and a higher potency for XO inhibition. However, little is known regarding febuxostat and its role in atherosclerosis. This prospective, randomized, open-label, blinded-endpoint clinical trial occurring at 48 sites in Japan between May 2014 and August 2018 sought to examine the relationship between febuxostat and atherosclerosis through measuring carotid intima-media thickness (IMT) progression in patients with asymptomatic hyperuricemia. A total of 483 adult participants (mean [SD] age = 69.1 [10.4] years, 19.7% female) with both maximum IMT of common carotid artery (CCA; ≥ 1.1 mm) and asymptomatic hyperuricemia (SUA ≥ 7.0 mg/dL) were allocated to either dose-titrated febuxostat (n = 239; 10 to 60 mg daily) or a non-pharmacological lifestyle modification for hyperuricemia (n = 244; e.g., diet, exercise changes) based on an intention-to-treat principle. Primary endpoint was change in mean IMT of the CCA from baseline to 24 months, with age, gender, history of type II diabetes, baseline SUA and IMT of the CCA as covariates. No significant differences between groups regarding CCA-IMT were found at baseline (p = 0.65). At 24 months, between group differences were not significant (mean difference -0.016 mm, 95% CI -0.051 to 0.019 mm, p = 0.37). Febuxostat did not demonstrate significant effects on the primary endpoint compared to the control group, nor did it have effects on other carotid ultrasonographic parameters. Regarding mean SUA values at 24 months, the febuxostat group was significantly lower than the control group (mean difference -2.62, 95% CI -2.86 to -2.38, p<0.001). While this study did not include a placebo control group, findings still suggest that 24 months of febuxostat treatment does not slow carotid atherosclerosis progression in Japanese individuals with asymptomatic hyperuricemia. +Click to read the study in PLOS Medicine +©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.