Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Dougherty B, Chan A. Dougherty B, & Chan A Dougherty, Brian, and Alex Chan. Intracranial atherosclerosis on 7T MRI and cognitive functioning – the SMART-MR study #TA. 2 Minute Medicine, 20 July 2020. McGraw-Hill, 2020. AccessNeurology. https://neurology.mhmedical.com/updatesContent.aspx?gbosid=551535§ionid=248697284APA Citation Dougherty B, Chan A. Dougherty B, & Chan A Dougherty, Brian, and Alex Chan. (2020). Intracranial atherosclerosis on 7t mri and cognitive functioning – the smart-mr study #ta. (2020). 2 minute medicine. McGraw-Hill. https://neurology.mhmedical.com/updatesContent.aspx?gbosid=551535§ionid=248697284.MLA Citation Dougherty B, Chan A. Dougherty B, & Chan A Dougherty, Brian, and Alex Chan. "Intracranial atherosclerosis on 7T MRI and cognitive functioning – the SMART-MR study #TA." 2 Minute Medicine McGraw-Hill, 2020, https://neurology.mhmedical.com/updatesContent.aspx?gbosid=551535§ionid=248697284. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Clip Full Chapter Figures Only Tables Only Videos Only Supplementary Content Top Intracranial atherosclerosis on 7T MRI and cognitive functioning – the SMART-MR study #TA by Brian Dougherty, Alex Chan Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. Among patients with vascular disease, high burden of atherosclerotic lesions in the posterior circulation as well as the posterior cerebral artery was associated with poorer memory and executive functioning. +Evidence Rating Level: 2 (Good) +The individual and societal burden of dementia continues to rise as the global population, on average, grows older. Though it is well known that cerebrovascular disease as a result of intracranial atherosclerosis (ICAS) can contribute to dementia and cognitive decline, less is known about this relationship with regards to premorbid cognitive functioning and the effect of artery-specific lesions. This prospective cohort study used 7 tesla (7T) vessel wall-MRI to explore the association between ICAS and cognitive function among 130 patients (mean [SD] age = 68  years, 88% male) with known vascular disease. Each patient’s neuropsychological status was assessed with a variety of tests, and individual testing scores were averaged to yield a composite Z-score. Imaging revealed that among the cohort, the average ICAS burden for the total circulation (ICASTC) was 8.5±5.7 lesions, for the anterior circulation (ICASAC) 5.3±3.2 lesions, and for the posterior circulation (ICASPC) 3.8±3.0 lesions. No significant association between ICASTC and memory was found (b = -0.02 per +1 lesion, 95% CI -0.05 to 0.00, where b is a linear regression coefficient representing the difference in Z-score per one lesion increase in ICAS burden), even after controlling for age, sex, education level, and reading ability. However, a significant association between ICASPC and memory was observed (b = -0.06 per +1 lesion, 95% CI -0.10 to -0.01). Additionally, when looking at individual arteries, ICAS burden in the posterior cerebral artery (ICASPCA) was associated with significant decline in both memory (b = -0.13 per +1 lesion, 95% CI -0.24 to -0.02) and executive function (b = -0.09 per +1 lesion, 95% CI -0.17 to -0.01). Non-significant associations between ICAS burden in the anterior cerebral artery (ICASACA) and decline in memory and executive function were observed. No significant associations were seen for the middle cerebral, internal carotid, vertebral, or basilar arteries. Overall, this study showed that among patients with a history of vascular disease, high ICAS burden in the posterior circulation as well as the posterior cerebral artery was associated with poorer memory and executive function. These findings may help inform understanding of how atherosclerosis of specific cerebral vessels contributes to the development of dementias. +Click to read the study in Neurology +©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.