Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Chan S, Shroff Karhade D. Chan S, & Shroff Karhade D Chan, Samuel, and Deepti Shroff Karhade. Ofatumumab may reduce annual relapse rates compared to teriflunomide in multiple sclerosis. 2 Minute Medicine, 11 August 2020. McGraw-Hill, 2020. AccessNeurology. https://neurology.mhmedical.com/updatesContent.aspx?gbosid=552835§ionid=249080126APA Citation Chan S, Shroff Karhade D. Chan S, & Shroff Karhade D Chan, Samuel, and Deepti Shroff Karhade. (2020). Ofatumumab may reduce annual relapse rates compared to teriflunomide in multiple sclerosis. (2020). 2 minute medicine. McGraw-Hill. https://neurology.mhmedical.com/updatesContent.aspx?gbosid=552835§ionid=249080126.MLA Citation Chan S, Shroff Karhade D. Chan S, & Shroff Karhade D Chan, Samuel, and Deepti Shroff Karhade. "Ofatumumab may reduce annual relapse rates compared to teriflunomide in multiple sclerosis." 2 Minute Medicine McGraw-Hill, 2020, https://neurology.mhmedical.com/updatesContent.aspx?gbosid=552835§ionid=249080126. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Clip Full Chapter Figures Only Tables Only Videos Only Supplementary Content Top Ofatumumab may reduce annual relapse rates compared to teriflunomide in multiple sclerosis by Samuel Chan, MD; Deepti Shroff Karhade Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. In this double-blind, randomized phase 3 trial, patient treated with ofatumumab had a lower annualized relapse rate in multiple sclerosis compared to those treated with teriflunomide +2. The ofatumumab treatment group had less disability worsening, improved number of enhancing lesions per MRI scans, and lower serum neurofilament light chains levels. However, no differences in brain volume was found +Evidence Rating Level: 1 (Excellent) Study Rundown: + +Ofatumumab is a CD-20 antibody that selectively depletes B cells while teriflunomide targets both the B and T-cell populations. This trial aimed to evaluate the efficacy and safety of injectable ofatumumab compared to oral teriflunomide in patients with multiple sclerosis. It was determined that treatment with ofatumumab reduced the annualized relapse rate compared to teriflunomide. Ofatumumab treatment was also associated with improved secondary endpoints such as less Expanded Disability Status Scale score regressions at 3 and 6 months but no significant improvement events were shown. MRI detected lesions and serum neurofilament light chain levels were improved in the ofatumumab group compared to the teriflunomide group. The main safety profile difference was an increased incidence of injection-related reactions in the ofatumumab group. This study was limited by the follow-up time as long term adverse events such as the development of neoplasms and mortality differences were not adequately assessed. Taken together, this study demonstrated that ofatumumab is a superior alternative to oral teriflunomide in the treatment of multiple sclerosis with some minor increases in the incidence of injected related reactions. +Click to read the study in NEJM +Relevant Reading: CD20 monoclonal antibodies for the treatment of multiple sclerosis: up-to-date In-Depth [randomized controlled trial]: + +This was a 1.6 year, double-blind, double-dummy phase 3 trial with two identical trials with a total of 946 patients with multiple sclerosis with a relapsing-remitting course or a secondary progressive course. Ages of patients ranged from 18 to 55 years. Patients were randomly assigned 1:1 to receive ofatumumab or oral teriflunomide with appropriate placebos. The primary efficacy endpoint demonstrated that ofatumumab improved the adjusted annualized relapse rate (-0.11 [95% CI -0.16 to -0.06], p <0.001) in trial 1 and trial 2 (-0.15 [95% CI -0.20 to -0.09], p <0.001). Secondary endpoints showed less disability worsening events at 3 months (HR 0.66 [95% CI 0.50 to 0.86]), at 6 months (HR 0.68 [95% cI 0.50 to 0.92]) but no improvements at 6 months (HR 1.35 [95% CI 0.95 to 1.92]) in the ofatumamab group. Furthermore, MRI detected lesions and serum neurofilament light chain concentrations were significantly lower on ofatumumab compared to teriflunomide. Brain volume change was not significantly different between groups. Serious adverse events were reported in 9% of ofatumumab patients and 8% of teriflunomide patients. Injection-related systemic reactions were reported in 20% of ofatumumab patients and 15% of placebo injections while injection-site reactions occurred in 11% and 6% respectively. +©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.