This book is a proud product of many leading academic physicians at multiple medical institutions including Columbia University College of Physicians and Surgeons, UMDNJ Robert Wood Johnson Medical School, Mount Sinai School of Medicine, Thomas Jefferson University Jefferson Medical College, and University of California at Los Angeles David Geffen Medical School. First I would like to express my grateful heart to Anne Sydor, Executive Editor at McGraw-Hill, who has been supportive of the idea from the beginning and to the production staff Christine Diedrich, Karen Edmonson, and Catherine Saggese who worked diligently to bring the book to fruition. I would like to sincerely thank every contributing author especially those who served kindly as the section editors: Neeraj Badjatia, MD, Jan Claassen, MD, PhD, Stephan A. Mayer, MD, E. Sander Connolly, MD, Joseph Meltzer, MD, Joseph Parrillo, MD, R. Phillip Dellinger, MD, Lawrence S. Weisberg, MD, Louis Aledort, MD, and especially Fred Rincon, MD, who has been incredibly helpful to me throughout the entire process. Without the efforts from all the authors and section editors, it would not have been possible to successfully produce this textbook. I would like to also thank George C. Newman, MD, PhD who has kindly offered the Foreword.