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APPENDIX: LABORATORY VALUES OF CLINICAL IMPORTANCE

Alexander Kratz; Michael A. Pesce; Robert C. Basner; Andrew J. Einstein

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    AMA Citation
    Kratz A, Pesce MA, Basner RC, Einstein AJ. Kratz A, Pesce M.A., Basner R.C., Einstein A.J. Kratz, Alexander, et al.LABORATORY VALUES OF CLINICAL IMPORTANCE. In: Hauser SL, Josephson S. Hauser S.L., Josephson S Eds. Stephen L. Hauser, and S. Andrew Josephson.eds. Harrison's Neurology in Clinical Medicine, 4e New York, NY: McGraw-Hill; 2017. http://neurology.mhmedical.com/content.aspx?bookid=2207&sectionid=169310966. Accessed October 15, 2019.
    MLA Citation
    Kratz A, Pesce MA, Basner RC, Einstein AJ. Kratz A, Pesce M.A., Basner R.C., Einstein A.J. Kratz, Alexander, et al.. "LABORATORY VALUES OF CLINICAL IMPORTANCE." Harrison's Neurology in Clinical Medicine, 4e Hauser SL, Josephson S. Hauser S.L., Josephson S Eds. Stephen L. Hauser, and S. Andrew Josephson. New York, NY: McGraw-Hill, 2017, http://neurology.mhmedical.com/content.aspx?bookid=2207&sectionid=169310966.

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INTRODUCTION

This Appendix contains tables of reference values for common laboratory tests. A variety of factors can influence reference values. Such variables include the population studied, the duration and means of specimen transport, laboratory methods and instrumentation, and even the type of container used for collection of the specimen. The reference or "normal" ranges given in this Appendix may therefore not be appropriate for all laboratories, and these values should only be used as general guidelines. Whenever possible, reference values provided by the laboratory performing the testing should be used in interpretation of laboratory data. Values supplied in this Appendix reflect typical reference ranges in nonpregnant adults. Pediatric reference ranges and values in pregnant patients may vary significantly from the data presented in the Appendix.

In preparing the Appendix, the authors have taken into account the fact that the system of international units (SI, système international d'unités) is used in most countries and in some medical journals. However, clinical laboratories may continue to report values in "traditional" or conventional units. Therefore, both systems are provided in the Appendix. The dual system is also used in the text except for those instances in which the numbers remain the same and only the terminology is changed (mmol/L for meq/L or IU/L for mIU/mL), when only the SI units are given.

TABLE 1HEMATOLOGY AND COAGULATION
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TABLE 1HEMATOLOGY AND COAGULATION
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ANALYTE SPECIMEN SI UNITS CONVENTIONAL UNITS
Activated clotting time WB 70–180 s 70–180 s
Activated protein C resistance (factor V Leiden) P Not applicable Ratio >2.1
ADAMTS13 activity P ≥0.67 ≥67%
ADAMTS13 inhibitor activity P Not applicable ≤0.4 U
ADAMTS13 antibody P Not applicable ≤18 U
Alpha2 antiplasmin P 0.87–1.55 87–155%
Antiphospholipid antibody panel
 PTT-LA (lupus anticoagulant screen) P Negative Negative
 Platelet neutralization procedure P Negative Negative
 Dilute viper venom screen P Negative Negative
Anticardiolipin antibody S
 IgG 0–15 arbitrary units 0–15 GPL
 IgM 0–15 arbitrary units 0–15 MPL
Beta-2 glycoprotein 1 antibodies S
 IgG 0–20 arbitrary units 0–20 SGU
 IgM 0–20 arbitrary units 0–20 SMU
Antithrombin III P
 Antigenic 220–390 mg/L 22–39 mg/dL
 Functional 0.7–1.30 U/L 70–130%
Anti-Xa assay (heparin assay) P
 Unfractionated heparin 0.3–0.7 kIU/L 0.3–0.7 IU/mL
 Low-molecular-weight heparin 0.5–1.0 kIU/L 0.5–1.0 IU/mL
 Danaparoid (Orgaran) 0.5–0.8 kIU/L 0.5–0.8 IU/mL
Autohemolysis test WB 0.004–0.045 0.4–4.50%
Autohemolysis test with glucose WB 0.003–0.007 0.3–0.7%
Bleeding time (adult) <7.1 min <7.1 min
C4 binding protein P 305–695 mg/L 30.5–69.5 mg/dL
S 275–604 mg/L 27.5–60.4 mg/dL
Clot retraction WB 0.50–1.00/2 h 50–100%/2 h
Cryofibrinogen P Negative Negative
D-dimer P 220–740 ng/mL FEU 220–740 ng/mL FEU
Differential blood count WB
Relative counts:
 Neutrophils 0.40–0.70 40–70%
 Bands 0.0–0.05 0–5%
 Lymphocytes 0.20–0.50 20–50%
 Monocytes 0.04–0.08 4–8%
 Eosinophils 0.0–0.6 0–6%
 Basophils 0.0–0.02 0–2%
Absolute counts:
 Neutrophils 1.42–6.34 × 109/L 1420–6340/mm3
 Bands 0–0.45 × 109/L 0–450/mm3
 Lymphocytes 0.71–4.53 × 109/L 710–4530/mm3
 Monocytes 0.14–0.72 × 109/L 140–720/mm3
 Eosinophils

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