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Chapter 8: The Cerebellum & Approach to Ataxia

CHAPTER SUMMARY FROM CURRENT DIAGNOSIS & TREATMENT

For a clinical review of the topic in Current Diagnosis & Treatment, 3e please go to Chapter 16: Ataxia & Cerebellar Disease.

INTRODUCTION

The output of the motor cortex (and the adjacent premotor and supplementary cortices) is shaped by input from the basal ganglia and cerebellum. The basal ganglia and cerebellum participate in corticocortical loops that begin and end in cortical motor regions. The basal ganglia are involved in the initiation and control of movements (see Ch. 7), and the cerebellum is involved in the coordination of movements. Both structures are also involved in cognition and eye movements. Lesions of the cerebellum can lead to incoordination of movements (ataxia), imprecision of movements (dysmetria), difficulty with rapid alternating movements (dysdiadochokinesia), truncal and gait instability, and difficulty with articulation of speech (dysarthria). Due to cerebellar involvement in oculomotor and vestibular function, cerebellar lesions can also cause nystagmus, vertigo, nausea, and vomiting.

ANATOMY & FUNCTION OF THE CEREBELLUM

Overall Structure of the Cerebellum

Like the brain, the cerebellum has two hemispheres consisting of a cortex, deep white matter, and deep gray matter (the bilateral dentate, emboliform, globose, and fastigial nuclei) (Fig. 8–1). At the midline, a cerebellar structure called the vermis lies between the hemispheres. The midline vermis controls coordination of the middle of the body, so pathology of the vermis leads to truncal and gait instability. The laterally placed cerebellar hemispheres control the lateral parts of the body: the limbs. Therefore, lesions of one or both cerebellar hemispheres can cause limb ataxia. Lesions in the cerebellar hemispheres cause deficits in the arm and/or leg ipsilateral to the affected hemisphere (in contrast to lesions of the cerebral hemispheres which cause deficits in the arm and/or leg contralateral to the affected hemisphere).

FIGURE 8–1

Anatomy of the cerebellum. A: Schematic posterior view of the cerebellum. B: Schematic posterior view of the brainstem with the cerebellum removed, demonstrating the three cerebellar peduncles. C: Schematic anterior view of the cerebellum with the brainstem removed. D: Schematic midsagittal view of the cerebellum. E: T1-weighted MRI, sagittal view. F: Schematic axial section of the cerebellum at the level of the pons and middle cerebellar peduncle demonstrating the deep cerebellar nuclei. Reproduced with permission from Martin J: Neuroanatomy Text and Atlas, 4th ed. New York, NY: McGraw Hill; 2012.

Three diagrams, A through C, of the structure of the cerebellum. Image E and diagrams D and F depict the structure of the cerebellum.
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Three diagrams, A through C, of the structure of the cerebellum. Image E and diagrams D and F depict the structure of the cerebellum.
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The left and right flocculi and the midline nodulus (together referred to as the flocculonodular lobe) are anterior cerebellar structures involved in vestibular function and eye movements.

The Cerebellar Peduncles

In order to coordinate movements, ...

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