TY - CHAP M1 - Book, Section TI - Preemptive Analgesia A1 - Parikh, Amar A1 - Simopoulos, Thomas T. A2 - Bajwa, Zahid H. A2 - Wootton, R. Joshua A2 - Warfield, Carol A. PY - 2016 T2 - Principles and Practice of Pain Medicine, 3e AB - The understanding of postoperative pain has evolved greatly during the past half century. Many laboratory investigations have established that peripheral tissue injury during surgery can trigger a prolonged state of spinal cord excitation. A reduction in neuronal thresholds in the central nervous system (CNS) is thought to amplify pain in postsurgical patients. Preemptive analgesia is an antinociceptive treatment targeted to block CNS hyperexcitability and leads to a reduced postoperative pain state. This treatment also has the long-term goals of facilitating rapid return to usual baseline function as well as decreasing the risk of chronic pain. However, despite numerous investigations, the clinical relevance of such treatment remains in controversy. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - neurology.mhmedical.com/content.aspx?aid=1131934717 ER -