TY  - CHAP
M1  - Book, Section
TI  - Nonsteroidal Anti-inflammatory Drugs
A1  - Simon, Lee S.
A2  - Bajwa, Zahid H.
A2  - Wootton, R. Joshua
A2  - Warfield, Carol A.
PY  - 2016
T2  - Principles and Practice of Pain Medicine, 3e
AB  - Nonsteroidal  anti-inflammatory  drugs  (NSAIDs)  are  anti-inflammatory,  analgesic,  and  antipyretic  agents.  They  are  used  to  reduce  pain,  decrease  stiffness,  and  improve  function  in  patients  with  osteoarthritis  (OA),  rheumatoid  arthritis  (RA),  and  other  forms  of  arthritis.  They  are  also  used  for  the  treatment  of  pain  including  headache,  dysmenorrhea,  and  postoperative  pain.1-3  It  is  not  known  whether  NSAID  effectiveness  results  from  the  anti-inflammatory  or  analgesic  effects  or  from  other  possible  mechanisms.4  There  are  at  least  20  different  NSAIDs  currently  available  in  the  United  States  (Table  74-1).  Cyclooxygenase-2  selective  inhibitors  (COX-2  inhibitors  [celecoxib]),  have  similar  efficacy  but  with  significantly  decreased  gastrointestinal  (GI)  and  platelet  effects.5-7  Several  topical  NSAIDs  including  diclofenac  or  salicylates  for  chronic  pain  have  been  approved  in  the  United  States;  however,  similar  drugs  have  been  available  in  Europe  for  a  number  of  years.  One  study  of  a  diclofenac  liquid  included  an  oral  diclofenac  comparator  demonstrating  no  difference  in  efficacy  from  the  topical  agent  in  chronic  dosing  in  treatment  of  the  pain  of  osteoarthritis  of  the  knee.8  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - neurology.mhmedical.com/content.aspx?aid=1131936965
ER  -