TY - CHAP M1 - Book, Section TI - The Neurobiology of Depression: An Integrated Systems-Level, Cellular–Molecular and Genetic Overview A1 - Perez, David A1 - Eldaief, Mark A1 - Epstein, Jane A1 - Silbersweig, David A1 - Stern, Emily A2 - Barsky, Arthur J. A2 - Silbersweig, David A. A2 - Boland, Robert J. PY - 2016 T2 - Depression in Medical Illness AB - Depression is a highly prevalent and disabling mental illness characterized primarily by abnormalities of mood, cognition and behavior. Individuals with major depression frequently experience anhedonia, depressed mood, negative self-referential thinking, impaired concentration, suicidal ideation, abnormal psychomotor activity, and variable changes in appetite and sleep. Major depression is among the most studied idiopathic psychiatric conditions, with an increasingly well-understood neurobiology. These insights are a pre-requisite to the development of more targeted therapeutic strategies, and can be helpful in understanding this disorder in the context of medical illness. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - neurology.mhmedical.com/content.aspx?aid=1138124280 ER -