TY - CHAP M1 - Book, Section TI - Renal Replacement Therapies A1 - Davenport, Andrew A2 - Lee, Kiwon PY - 2017 T2 - The NeuroICU Book, 2e AB - A 26-year-old woman was admitted following a horse-riding accident. She had fractured her femur and suffered an intracranial hemorrhage. Postoperatively she required mechanical ventilation and then developed a respiratory tract infection. On the 3rd hospital day, her urine output had fallen to 0.5 mL/kg/h, and her serum creatinine had risen from 0.5 mg/dL on admission to 1.24 mg/dL. At this stage her intracranial pressure (ICP), measured with an intraventricular catheter, remained elevated at 35 mm Hg, with a mean arterial blood pressure of 90 mm Hg. In view of the increase in creatinine and decrease in urine output, a fluid challenge was given to try and prevent progression of acute kidney injury (AKI), to exclude a volume-responsive reversible cause of AKI (Table 48-1). However, by the following day her urine output had fallen to 0.3 mL/kg/h, and the creatinine level had increased to 2.0 mg/dL. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/20 UR - neurology.mhmedical.com/content.aspx?aid=1143957640 ER -