TY  - CHAP
M1  - Book, Section
TI  - Approach to Neurocognitive Disorders 
A1  - McGinnis, Scott M.
A2  - Silbersweig, David A.
A2  - Safar, Laura T.
A2  - Daffner, Kirk R.
PY  - 2021
T2  - Neuropsychiatry and Behavioral Neurology: Principles and Practice
AB  - The  purpose  of  this  chapter  is  to  provide  a  framework  for  approaching  cognitive  disorders  based  on  anatomical  localization  and  time  course.  In  so  doing  we  will  review  key  clinical  considerations  in  the  diagnosis  and  management  of  conditions  with  acute/subacute  onset  versus  those  with  insidious  onset  (Figure  20-1).  In  each  case,  it  is  important  to  know  the  cardinal  features  of  the  more  common  conditions  as  well  as  atypical  features  that  should  prompt  consideration  of  alternative,  less  common  conditions.  For  conditions  with  acute/subacute  onset  this  involves  understanding  core  aspects  of  delirium  (exceedingly  common)  and  features  that  might  alternatively  suggest  conditions  in  the  differential  diagnosis  of  rapidly  progressive  dementia  (RPD;  relatively  less  common).  For  conditions  with  insidious  onset,  the  chapter  reviews  a  basic  workup  and  considers  a  high-level  distinction  between  two  categories  of  presentations:  nonprogressive  disorders,  and  gradually  progressive  neurodegenerative  (±vascular)  diseases.  Within  the  category  of  neurodegenerative  disorders,  we  will  explore  the  utility  of  a  comprehensive  diagnostic  formulation  encompassing  syndrome,  severity,  and  suspected  underlying  neuropathology.  The  chapter  concludes  by  examining  key  elements  of  relatively  more  common  conditions—late-onset,  amnesic,  and  dysexecutive  syndromes  associated  with  underlying  Alzheimer’s  disease  (AD)  and  Lewy  body  disease  (LBD)  neuropathology—and  atypical  features  that  might  suggest  relatively  less  common  conditions  such  as  non-amnesic  presentations  of  AD  and  syndromes  within  the  spectrum  of  frontotemporal  lobar  degeneration  (FTLD)  neuropathology.  
SN  - 
PB  - McGraw Hill
CY  - New York, NY
Y2  - 2024/04/20
UR  - neurology.mhmedical.com/content.aspx?aid=1178762987
ER  -