TY - CHAP M1 - Book, Section TI - Chapter 26. Malformations of the Nervous System in Relation to Ontogenesis A1 - Sarnat, Harvey B. A1 - Flores-Sarnat, Laura A2 - Carney, Paul R. A2 - Geyer, James D. PY - 2010 T2 - Pediatric Practice: Neurology AB - Embryonic development of the nervous system is a series of overlapping processes.1 To understand neural development, a traditional view of morphogenesis must be integrated with what we know about molecular genetic programming of the neural tube and fetal brain. Understanding these normal ontogenetic processes is necessary to comprehend neural malformations, which arise as disturbances in one or more of these processes. Malformations of the brain and spinal cord may be caused by genetic mutations or by environmental or acquired influences. Examples of acquired and environmental causes are teratogenic toxins and drugs, fetal ischemia and infarcts, intrauterine trauma from maternal trauma or invasive procedures, cerebral hemorrhages, and infections affecting the fetal brain. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - neurology.mhmedical.com/content.aspx?aid=6654458 ER -