TY - CHAP M1 - Book, Section TI - Demyelinating Diseases A1 - McCoyd, Matthew A1 - Salardini, Arash A2 - Salardini, Arash A2 - Biller, José Y1 - 2016 N1 - T2 - The Hospital Neurology Book AB - Multiple sclerosis (MS) is an autoimmune central nervous system (CNS) demyelinating disease characterized by inflammatory clinical relapses and gradual neurodegeneration. The etiology of MS is multifactorial and involves both genetic and environmental factors. MS diagnosis is made on clinical and imaging grounds. The basic paradigm was first introduced in the 1960s and is referred to as Schumacker’s1 criteria after its first author. Schumacker set out 6 criteria for the diagnosis of definite MS:Age between 10 and 50 yearsPresence of objective clinical signsLesions being predominantly in the white matterTwo or more lesions in the CNS separated in spaceThe attacks being separated in timeEpisodes lasting more than 24 hours and spaced more than one month apartDocumented progression for more than 6 months.The rule out of other pathologies SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - neurology.mhmedical.com/content.aspx?aid=1127048484 ER -