TY - CHAP M1 - Book, Section TI - Pathophysiology of Pain A1 - Cohen, Stephen A. A2 - Bajwa, Zahid H. A2 - Wootton, R. Joshua A2 - Warfield, Carol A. Y1 - 2016 N1 - T2 - Principles and Practice of Pain Medicine, 3e AB - The Decade of Pain Control and Research (DPCR) legislation passed by the 106th Congress helped promulgate an extraordinary number of scientific inquiries into the mechanisms and treatment of pain. In the decade before Senator Hatch introduced the Bill, a PubMed search of the term “pathophysiology of pain” retrieved 53 articles. In the DPCR, the same search yielded 32,283 articles. In the ten years since the publication of the second edition of this textbook in 2004, nearly 48,000 articles have been published. The accelerated rate of publications has begun to slow; but it was hoped that such research growth would continue for three reasons: (1) For humane considerations, we simply need more effective and safer medications for better pain management. (2) The cost of pain to society is colossal–nearly $55 billion per year by one estimate. (3) Improved scientific and technological knowledge about pain pathways drives pain drug discovery research and development to meet demand.1 However, by the end of the DPCR, many impediments to using evidence-based pain management methods still remained, and federal economic support was waning.2,3 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - neurology.mhmedical.com/content.aspx?aid=1131930391 ER -