TY - CHAP M1 - Book, Section TI - Depression and Neurologic Illness A1 - Safar, Laura A1 - Sullivan, John A1 - Baslet, Gaston A1 - Harder, Jessica A1 - Morrissey, Laura A1 - Raj, Shreya A1 - Daffner, Kirk A1 - Silbersweig, David A2 - Barsky, Arthur J. A2 - Silbersweig, David A. A2 - Boland, Robert J. Y1 - 2016 N1 - T2 - Depression in Medical Illness AB - Depression is the most highly prevalent neuropsychiatric syndrome across all neurologic illnesses (Fig. 5-1). The relationship between depression and neurologic illness is complex in several aspects, including pathophysiology, clinical presentation, and response to treatment. Depression may sometimes be the direct result of brain pathology, very much like other neurological manifestations, such as cognitive or motor disturbances. In other cases, a more complex interplay of neurobiological, environmental, and coping mechanisms appears responsible for the development of depressive symptoms (Box 5-1). Neurologic illness may produce signs and symptoms that mimic depression, such as psychomotor retardation, apathy, concentration deficits, and sleep disorders, making the diagnosis of depression in the context of neurologic illness challenging. However, the identification and treatment of depression in these individuals is of fundamental importance, as this tends to improve the prognosis of the neurological disease. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - neurology.mhmedical.com/content.aspx?aid=1138124892 ER -