TY - CHAP M1 - Book, Section TI - Focal Seizures in Early Childhood A1 - Cross, J. Helen A2 - Duchowny, Michael A2 - Cross, J. Helen A2 - Arzimanoglou, Alexis Y1 - 2017 N1 - T2 - Pediatric Epilepsy AB - Several studies have demonstrated that seizure manifestations evolve according to developmental age. Although myelination is largely complete by two years of age, clinical seizure manifestations continue to evolve beyond this age (probably reflecting the caudorostral pattern of brain development), with an adult pattern of semiology unlikely before age 6 years. A high index of suspicion is therefore required when evaluating the clinical description of events for focality. The assessment will have obvious management implications, particularly for the diagnosis of an epilepsy syndrome. Most studies evaluating seizure semiology have been performed in surgical cohorts, where documentation of seizure type is made with video EEG telemetry and confirmed by seizure freedom after removal of the suspect area. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - neurology.mhmedical.com/content.aspx?aid=1138410269 ER -