TY - CHAP M1 - Book, Section TI - Ion Channels A1 - Kandel, Eric R. A1 - Koester, John D. A1 - Mack, Sarah H. A1 - Siegelbaum, Steven A. Y1 - 2021 N1 - T2 - Principles of Neural Science, 6e AB - SIGNALING IN THE BRAIN DEPENDS on the ability of nerve cells to respond to very small stimuli with rapid and large changes in the electrical potential difference across the cell membrane. In sensory cells, the membrane potential changes in response to minute physical stimuli: Receptors in the eye respond to a single photon of light; olfactory neurons detect a single molecule of odorant; and hair cells in the inner ear respond to tiny movements of atomic dimensions. These sensory responses ultimately lead to the firing of an action potential during which the membrane potential changes at up to 500 volts per second. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/10/13 UR - neurology.mhmedical.com/content.aspx?aid=1180640095 ER -