TY - CHAP M1 - Book, Section TI - Rehabilitation of the Organ Transplant Patient A1 - Feldman, Dorianne R. A1 - Van, Stephanie A1 - Edmiston, Travis A1 - Mayer, R. Samuel A2 - Mitra, Raj Y1 - 2019 N1 - T2 - Principles of Rehabilitation Medicine AB - ORGAN TRANSPLANTATION IS ONE OF THE MOST complex surgical procedures in modern medicine. In 1954, Dr. Joseph Murray and Dr. David Hume of Brigham Hospital in Boston first successfully transplanted a human kidney from a living donor to his identical twin recipient. In 1967, Dr. Christiaan Barnard in Cape Town, South Africa, was the first to perform a human heart transplant. Notably, in the 1970s, Dr. Jean-Francois Borel discovered cyclosporine, a derivative of soil fungus that remains a key component in most transplant patients’ immunosuppressive therapy regimens today. These initial efforts did not have encouraging survival rates and over the next few decades, advances in immunosuppressant therapies and tissue typing helped to improve transplant procedure outcomes and prolong survival. Given that transplant patients are surviving longer, the ultimate goal of organ transplantation, recovery, and rehabilitation is to return these patients to the highest level of function and livelihood as possible. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - neurology.mhmedical.com/content.aspx?aid=1182784164 ER -