TY - CHAP M1 - Book, Section TI - Chapter 9. Genetics of Parkinson's Disease and Parkinsonian Disorders A1 - West, Andrew B. A2 - Watts, Ray L. A2 - Standaert, David G. A2 - Obeso, Jose A. Y1 - 2012 N1 - T2 - Movement Disorders, 3e AB - Parkinson's disease (PD) is the second most common neurodegenerative disease, with some estimates suggesting over one million Americans suffering with symptoms. The pathological hallmark of PD that gives rise to the trademark motor complications is the loss of melanized tyrosine-hydroxylase-positive dopaminergic neurons in the substantia nigra pars compacta. The fundamental mechanisms underlying the loss of this indispensable nucleus of neurons remain largely a mystery. Additional lesions and cell loss likewise occur in many regions throughout the central and peripheral nervous system, probably responsible for the diverse and debilitating non-motor symptoms associated with the disease.1, 2 SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - neurology.mhmedical.com/content.aspx?aid=55792363 ER -