TY  - CHAP
M1  - Book, Section
TI  - Central Nervous System Neoplasms
A1  - Mandigo, Christopher E.
A1  - Bruce, Jeffrey N.
A2  - Brust, John C.M.
PY  - 2019
T2  - CURRENT Diagnosis & Treatment: Neurology, 3e
AB  - Tumors  of  the  nervous  system  comprise  a  diverse,  heterogeneous  group  of  neoplastic  lesions  that  affect  every  age  group  and  every  element  of  the  central  and  peripheral  nervous  systems.  The  cause  of  most  adult  and  pediatric  central  nervous  system  (CNS)  tumors  is  largely  unknown.  A  few  rare  genetic  syndromes  play  a  clear  and  independent  role  in  brain  tumor  development,  including  neurofibromatosis  types  1  and  2,  Li-Fraumeni  syndrome,  Gardner  syndrome,  Turcot  syndrome,  and  von  Hippel-Lindau  disease  (Table  12–1).  Independent  of  these  disorders,  a  family  history  of  malignant  brain  tumors  is  a  minor  risk  factor  for  developing  brain  tumors.  Most  CNS  tumors  are  thought  to  be  sporadic  in  origin,  as  familial  and  genetic  associations  play  a  role  in  only  about  5%  of  all  cases.  Nonetheless,  many  sporadic  tumors  arise  as  a  result  of  combined  somatic  mutations  that  activate  oncogenes  such  as  platelet-derived  growth  factor  and  inactivate  tumor  suppressor  genes  such  as  p53.  The  role  of  environmental  factors—physical,  chemical,  or  infectious—in  causing  such  mutations  or  otherwise  acting  as  risk  factors  is  unknown.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/16
UR  - neurology.mhmedical.com/content.aspx?aid=1159968859
ER  -