TY - CHAP M1 - Book, Section TI - Addiction as a Neuropsychiatric Disease A1 - Rodriguez, Claudia P. A1 - Suzuki, Joji A2 - Silbersweig, David A. A2 - Safar, Laura T. A2 - Daffner, Kirk R. PY - 2021 T2 - Neuropsychiatry and Behavioral Neurology: Principles and Practice AB - Drug addiction is a chronic disease that is characterized by loss of control, cravings, and compulsive use despite negative consequences. As a neuropsychiatric disease, addiction is conceptualized as a cycle of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. The stages of the cycle are directed by activity and neuroadaptations that occur at different regions of the brain with repeated drug use. As reviewed in this chapter, key structures involved in each of these stages include the ventral tegmental area (VTA) in binge/intoxication, extended amygdala (including the bed of stria terminalis, nucleus accumbens, and amygdala) in withdrawal/negative affect and craving, and orbitofrontal cortex, basolateral amygdala, and hippocampus in preoccupation/anticipation.1 SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/03/29 UR - neurology.mhmedical.com/content.aspx?aid=1178762302 ER -