TY  - CHAP
M1  - Book, Section
TI  - Intracranial Neoplasms and Paraneoplastic Disorders
A1  - Ropper, Allan H.
A1  - Samuels, Martin A.
A1  - Klein, Joshua P.
A1  - Prasad, Sashank
PY  - 2023
T2  - Adams and Victor's Principles of Neurology, 12e
AB  - The  importance  of  tumors  of  the  nervous  system  in  both  neurology  and  general  medicine  derives  from  their  great  variety;  the  numerous  neurologic  symptoms  they  cause;  the  destruction  and  displacement  of  brain  tissue  and  most  of  all,  their  lethality.  The  nature  of  practice  for  brain  tumors  has  continuously  changed  as  a  result  of  advances  in  anesthesiology,  stereotactic  and  microneurosurgical  techniques,  focused  radiation  therapy,  and  the  use  of  new  chemotherapeutic  agents.  Moreover,  our  understanding  of  the  genetic  aspects  of  brain  tumors  is  undergoing  vast  alteration,  which  offers  the  prospect  of  new  treatments.  Perhaps  the  largest  inception  in  the  field  of  brain  tumors  in  recent  years  has  been  the  WHO  2021  classification  system  (also  called  in  the  chapter,  WHO5)  which  is  based  largely  on  genetic  alterations  within  tumors,  some  of  which  are  pathogenic  and  most  of  which  align  with  prognosis  to  a  greater  extent  than  histologic  features,  which  in  the  past  had  dominated  our  ideas  about  these  disorders.  This  has  rearranged  nosology  in  the  field,  dropping  formerly  common  terminologies  and  introducing  new  ones  that  are  incorporated  into  appropriate  sections  of  this  chapter.  Deeper  study  of  genetic  variants  is  likely  to  continue  but  the  problem  of  defining  disease  categories  as  contrasted  with  surrogate  markers  of  tumor  behavior  will  take  time  to  resolve  and  we  are  currently  at  a  point  of  using  what  are  undoubtedly  transitional  classifications.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/10/14
UR  - neurology.mhmedical.com/content.aspx?aid=1199445449
ER  -