TY  - CHAP
M1  - Book, Section
TI  - Chapter 15. Pharmacological Treatment of Parkinson's Disease
A1  - Poewe, Werner
A1  - Mahlknecht, Philipp
A2  - Watts, Ray L.
A2  - Standaert, David G.
A2  - Obeso, Jose A.
PY  - 2012
T2  - Movement Disorders, 3e
AB  - The  first  empirical  attempts  of  a  pharmacological  treatment  of  Parkinson's  disease  (PD)  were  made  in  the  1860s  by  Ordenstein  and  Charcot  in  Paris  by  using  extracts  from  Hyscyamus  niger,Atropia  belladonna,  and  Datura  stramonium  containing  the  anticholinergic  compounds  hyoscine  and  scopolamine.1,2  With  the  development  of  synthetic  anticholinergic  drugs  in  the  1940s3  these  agents  became  the  mainstay  of  antiparkinsonian  drug  treatment.  However,  while  improving  tremor  and  rigidity,  they  had  little  effect  on  akinesia.4  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/16
UR  - neurology.mhmedical.com/content.aspx?aid=55794234
ER  -