TY - CHAP M1 - Book, Section TI - Infantile Spasms A1 - Lerner, Jason T. A1 - Matsumoto, Joyce H. A1 - Wu, Joyce Y. A2 - Sirven, Joseph I. A2 - Stern, John M. PY - 2011 T2 - Atlas of Video-EEG Monitoring AB - Infantile spasms, also known as infantile epileptic encephalopathy (IEE), is a severe form of childhood epilepsy that typically manifests within the first year of life and appears to be tied to a particular neurodevelopmental period. A high-amplitude, chaotic interictal electroencephalographic (EEG) background, known as hypsarrhythmia, is often seen in association with infantile spasms. In the wake of infantile spasms, the majority of children are left with significant cognitive delay. The triad of infantile spasms, developmental arrest or regression, and the characteristic EEG background of hypsarrhythmia has been dubbed West syndrome, after the English physician William West, who first provided a detailed description of spasms in 1841, as seen in his 4-month-old son.1 The broader term epileptic spasms is sometimes used to denote events of a similar semiology that tend to present in a slightly older age range and are not associated with hypsarrhythmia on EEG. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - neurology.mhmedical.com/content.aspx?aid=1103049656 ER -