TY - CHAP M1 - Book, Section TI - Signaling at the Nerve-Muscle Synapse: Directly Gated Transmission PY - 2014 T2 - Principles of Neural Science, Fifth Edition AB - The Neuromuscular Junction Is a Well-Studied Example of Directly Gated Synaptic TransmissionThe Motor Neuron Excites the Muscle by Opening Ligand-Gated Ion Channels at the End-PlateThe End-Plate Potential Is Produced by Ionic Current Through Acetylcholine Receptor-ChannelsThe Ion Channel at the End-Plate Is Permeable to Both Sodium and PotassiumThe Current Through Single Acetylcholine Receptor-Channels Can Be Measured Using the Patch ClampIndividual Receptor-Channels Conduct All-or-None Unitary CurrentsFour Factors Determine the End-Plate CurrentThe Molecular Properties of the Acetylcholine Receptor-Channel Are KnownAn Overall ViewPostscript: The End-Plate Current Can Be Calculated from an Equivalent Circuit SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - neurology.mhmedical.com/content.aspx?aid=1101677912 ER -