RT Book, Section
A1 McCoyd, Matthew
A1 Salardini, Arash
A2 Salardini, Arash
A2 Biller, José
SR Print(0)
ID 1127048484
T1 Demyelinating Diseases
T2 The Hospital Neurology Book
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071845830
LK neurology.mhmedical.com/content.aspx?aid=1127048484
RD 2024/04/20
AB Multiple  sclerosis  (MS)  is  an  autoimmune  central  nervous  system  (CNS)  demyelinating  disease  characterized  by  inflammatory  clinical  relapses  and  gradual  neurodegeneration.  The  etiology  of  MS  is  multifactorial  and  involves  both  genetic  and  environmental  factors.  MS  diagnosis  is  made  on  clinical  and  imaging  grounds.  The  basic  paradigm  was  first  introduced  in  the  1960s  and  is  referred  to  as  Schumacker’s1  criteria  after  its  first  author.  Schumacker  set  out  6  criteria  for  the  diagnosis  of  definite  MS:Age  between  10  and  50  yearsPresence  of  objective  clinical  signsLesions  being  predominantly  in  the  white  matterTwo  or  more  lesions  in  the  CNS  separated  in  spaceThe  attacks  being  separated  in  timeEpisodes  lasting  more  than  24  hours  and  spaced  more  than  one  month  apartDocumented  progression  for  more  than  6  months.The  rule  out  of  other  pathologies