RT Book, Section A1 Perez, David A1 Eldaief, Mark A1 Epstein, Jane A1 Silbersweig, David A1 Stern, Emily A2 Barsky, Arthur J. A2 Silbersweig, David A. A2 Boland, Robert J. SR Print(0) ID 1138124280 T1 The Neurobiology of Depression: An Integrated Systems-Level, Cellular–Molecular and Genetic Overview T2 Depression in Medical Illness YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071819084 LK neurology.mhmedical.com/content.aspx?aid=1138124280 RD 2024/04/25 AB Depression is a highly prevalent and disabling mental illness characterized primarily by abnormalities of mood, cognition and behavior. Individuals with major depression frequently experience anhedonia, depressed mood, negative self-referential thinking, impaired concentration, suicidal ideation, abnormal psychomotor activity, and variable changes in appetite and sleep. Major depression is among the most studied idiopathic psychiatric conditions, with an increasingly well-understood neurobiology. These insights are a pre-requisite to the development of more targeted therapeutic strategies, and can be helpful in understanding this disorder in the context of medical illness.