RT Book, Section A1 Wolfe, David A1 Goldberg, Hilary A2 Barsky, Arthur J. A2 Silbersweig, David A. A2 Boland, Robert J. SR Print(0) ID 1138126494 T1 Depression in Pulmonary Disease T2 Depression in Medical Illness YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071819084 LK neurology.mhmedical.com/content.aspx?aid=1138126494 RD 2024/04/18 AB Diseases of the lung are diverse in pathophysiology, course, and treatment, creating several challenges for the assessment and treatment of comorbid depression. The anxiety associated with shortness of breath—at times nearly indistinguishable from that of a panic—may be the most prominent psychiatric symptom in individuals with lung disease. However, depression of various degrees is also common (Fig. 16-1) and associated with significant morbidity and mortality. This chapter will first review the major classes of pulmonary diseases and the known epidemiology of depression in these groups. Subsequent sections will discuss over-arching pathophysiologic mechanisms, as well as the novel features of depression onset, progression, and treatment in this population.