RT Book, Section
A1 Hirsch, Edouard
A2 Duchowny, Michael
A2 Cross, J. Helen
A2 Arzimanoglou, Alexis
SR Print(0)
ID 1138410966
T1 Acquired Epileptic Aphasia (Landau–Kleffner Syndrome)
T2 Pediatric Epilepsy
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9780071496216
LK neurology.mhmedical.com/content.aspx?aid=1138410966
RD 2024/04/19
AB Acquired  epileptic  aphasia1  is  an  epileptic  syndrome  described  in  the  International  Classification  of  Epilepsies  by  the  eponym  Landau–Kleffner  syndrome  (LKS).  Typical  LKS2,3  is  part  of  the  epileptic  encephalopathy  of  late  childhood  defined  by1:  age  of  onset  ranging  from  3  to  10  years  in  children  with  previously  normal  language  development;2  insidious  or  abrupt  acquired  aphasia  with  verbal  auditory  agnosia;  behavior  disturbances  (attention  deficit  and  hyperactivity);3  seizures  that  may  be  nocturnal,  focal  motor,  secondarily  generalized,  or  atypical  absences  with  an  awake  electroencephalographic  (EEG)  showing  focal  or  multifocal  spikes-and-waves  predominantly  over  the  temporal  regions  (Fig.  30–1);4  and  sleep  EEG  reveals  activation  of  interictal  EEG  abnormalities  and,  during  the  course  of  the  syndrome  in  the  acute  phase,  nonrapid  eye  movement  (NREM)  subcontinuous  or  continuous  spike-waves  during  sleep  (CSWS)  (Fig.  30–1).