RT Book, Section A1 Tinuper, Paolo A1 Bisulli, Francesca A1 Provini, Federica A1 Geyer, James D. A1 Carney, Paul R. A2 Duchowny, Michael A2 Cross, J. Helen A2 Arzimanoglou, Alexis SR Print(0) ID 1138411863 T1 Treating Epilepsy in the Presence of Sleep Disorders T2 Pediatric Epilepsy YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071496216 LK neurology.mhmedical.com/content.aspx?aid=1138411863 RD 2024/03/29 AB Sleep disorders have an adverse impact on daily living for both children and their caregivers.1 Sleep disturbance and lack of restful sleep can masquerade as a myriad of clinical problems, including inattention, depression, headache, and seizures. While most neurological disorders are well characterized during the waking state, descriptions of pathophysiology, signs and comorbidities are frequently poorly described during sleep. Physiologic changes associated with sleep can cause an alteration of signs and function during both REM (rapid eye movement) and non-REM (NREM) sleep. These changes may include alterations in muscle tone, central control of autonomic functions, and changes in cortical neurotransmitter system interaction and balance.