RT Book, Section
A1 Olanow, C. Warren
A1 Schapira, Anthony H.V.
A1 Obeso, Jose A.
A2 Hauser, Stephen L.
A2 Josephson, S. Andrew
SR Print(0)
ID 1145769683
T1 PARKINSON’S DISEASE AND OTHER MOVEMENT DISORDERS
T2 Harrison's Neurology in Clinical Medicine, 4e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259835865
LK neurology.mhmedical.com/content.aspx?aid=1145769683
RD 2024/04/18
AB Parkinson’s  disease  (PD)  is  the  second  commonest  neurodegenerative  disease,  exceeded  only  by  Alzheimer’s  disease  (AD).  Its  cardinal  clinical  features  were  first  described  by  the  English  physician  James  Parkinson  in  1817.  It  is  noteworthy  that  James  Parkinson  was  a  general  physician  who  captured  the  essence  of  this  condition  based  on  a  visual  inspection  of  a  mere  handful  of  patients.  It  is  estimated  that  approximately  1  million  persons  in  the  United  States,  1  million  in  Western  Europe,  and  5  million  worldwide  suffer  from  this  disorder.  PD  affects  men  and  women  of  all  races,  all  occupations,  and  all  countries.  The  mean  age  of  onset  is  about  60  years.  The  frequency  of  PD  increases  with  aging,  but  cases  can  be  seen  in  patients  in  their  20s  and  even  younger.  Based  on  the  aging  of  the  population  and  projected  demographics,  it  is  estimated  that  the  prevalence  of  the  disease  will  dramatically  increase  in  the  next  several  decades.