RT Book, Section A1 Hauser, Stephen L. A1 Goodin, Douglas S. A2 Hauser, Stephen L. A2 Josephson, S. Andrew SR Print(0) ID 1145770333 T1 MULTIPLE SCLEROSIS AND OTHER DEMYELINATING DISEASES T2 Harrison's Neurology in Clinical Medicine, 4e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259835865 LK neurology.mhmedical.com/content.aspx?aid=1145770333 RD 2024/04/24 AB Demyelinating disorders are immune-mediated conditions characterized by preferential destruction of central nervous system (CNS) myelin. The peripheral nervous system (PNS) is spared, and most patients have no evidence of an associated systemic illness. Multiple sclerosis, the most common disease in this category, is second only to trauma as a cause of neurologic disability beginning in early to middle adulthood.