RT Book, Section A1 Dalmau, Josep A1 Rosenfeld, Myrna R. A2 Hauser, Stephen L. A2 Josephson, S. Andrew SR Print(0) ID 1147190559 T1 PARANEOPLASTIC NEUROLOGIC SYNDROMES AND AUTOIMMUNE ENCEPHALITIS T2 Harrison's Neurology in Clinical Medicine, 4e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259835865 LK neurology.mhmedical.com/content.aspx?aid=1147190559 RD 2024/03/29 AB Paraneoplastic neurologic disorders (PNDs) are cancer-related syndromes that can affect any part of the nervous system (Table 50-1). They are caused by mechanisms other than metastasis or by any of the complications of cancer such as coagulopathy, stroke, metabolic and nutritional conditions, infections, and side effects of cancer therapy. In 60% of patients, the neurologic symptoms precede the cancer diagnosis. Clinically disabling PNDs occur in 0.5–1% of all cancer patients, but they affect 2–3% of patients with neuroblastoma or small-cell lung cancer (SCLC) and 30–50% of patients with thymoma or sclerotic myeloma.