RT Book, Section A1 Akyuz, Gulseren A1 Bektaşoğlu, Pınar Kuru A2 Mitra, Raj SR Print(0) ID 1159831569 T1 Neuropathic Pain T2 Principles of Rehabilitation Medicine YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9780071793339 LK neurology.mhmedical.com/content.aspx?aid=1159831569 RD 2024/10/10 AB NEUROPATHIC PAIN (NP) HAS A COMPLEX, severe, and persistent character with varying intensity and duration. It may accompany many diseases but can also be related to an injury. This chapter provides an overview of NP, including the definition, history, epidemiology, and pathophysiology. Also, clinical manifestations, assessment methods, screening tests, and diagnostic tools are reviewed. The classification of NP syndromes with respect to their anatomic localization (peripheral nervous system, central nervous system, and mixed) will be investigated in detail, in addition to pharmacologic and onpharmacologic treatment options. First-line medication choice in the management of NP includes tricyclic antidepressants (TCAs), serotonin-norepinephrine reuptake inhibitors (SNRIs), anticonvulsants, opioids, cannabinoids, and topical agents.1 Physical therapy modalities such as superficial and deep heat applications, traction, laser, transcutaneous electrical nerve stimulation (TENS), and diadynamic and interferential electrical currents are more helpful when combined with therapeutic exercises. Psychotherapy, cognitive-behavioral therapy (CBT), and relaxation therapy are recommended in the management of NP. Noninvasive (repetitive transcranial magnetic stimulation [rTMS] and transcranial direct current stimulation [tDCS]) and invasive neuromodulation techniques (deep brain stimulation [DBS], motor cortex stimulation [MCS], and spinal cord stimulation [SCS]) are also focused on the treatment of NP.