RT Book, Section A1 Williams, Lisa M. A1 Fini, Habib Mofakham A1 Joyce, Nanette C. A2 Mitra, Raj SR Print(0) ID 1159834639 T1 Neuromuscular Disease: Motor Neuron Disorders T2 Principles of Rehabilitation Medicine YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9780071793339 LK neurology.mhmedical.com/content.aspx?aid=1159834639 RD 2024/10/11 AB Motor neuron diseases (mnds) are a heterogeneous group of neurologic conditions characterized by corticospinal tract and anterior horn cell degeneration of the brain and spinal cord1 (Fig. 71–1). While the etiology of MNDs is broad and not clearly elucidated, there is evidence supporting multifactorial processes that can be inherited genetically or acquired sporadically through environmental exposures such as toxins, infections, and autoimmune or other causes.2–8 The common pathology is the destruction of motor neurons and encompasses disorders with selective loss of lower motor neurons (LMNs), upper motor neurons (UMNs), or a combination of both.2 This results in muscle weakness and disability with loss of normal limb, speech, swallow, and respiratory functions.