RT Book, Section A1 Erkkinen, Michael A1 Putcha, Deepti A1 Daffner, Kirk R. A2 Silbersweig, David A. A2 Safar, Laura T. A2 Daffner, Kirk R. SR Print(0) ID 1178762119 T1 Focal Neurobehavioral Syndromes T2 Neuropsychiatry and Behavioral Neurology: Principles and Practice YR 2021 FD 2021 PB McGraw Hill PP New York, NY SN 9781260117103 LK neurology.mhmedical.com/content.aspx?aid=1178762119 RD 2024/04/25 AB One of the fundamental working hypotheses of modern neuroscience is that the functioning of the brain permits and shapes the expression of the mind. Cognitive, perceptual, affective, and behavioral capacities and limits are determined by neural structures and the dynamic flow of information within them. The shifting contents of momentary experience are the product of precisely coordinated, ever-changing combinations of electrical activity within richly connected neural networks. Put another way, neural states encode mental experiences. These complex neurobiological processes are scaffolded by evolution via inherited factors, animated by environmental inputs, and chiseled by experience and learning. The system learns about itself and the workings of its environment through continuous prediction and feedback, self-generated actions and environmental inputs shape this dynamic neural circuitry. Brain-behavior relationships are complex but patterned: specific neural activities support specific mental states and localized brain dysfunction leads to focal neurobehavioral changes. This schematic framework relating brain and mind is embedded in the clinical fields of behavioral neurology and neuropsychiatry and serves as this chapter’s main axiom.