RT Book, Section
A1 Rodriguez, Claudia P.
A1 Suzuki, Joji
A2 Silbersweig, David A.
A2 Safar, Laura T.
A2 Daffner, Kirk R.
SR Print(0)
ID 1178762302
T1 Addiction as a Neuropsychiatric Disease
T2 Neuropsychiatry and Behavioral Neurology: Principles and Practice
YR 2021
FD 2021
PB McGraw Hill
PP New York, NY
SN 9781260117103
LK neurology.mhmedical.com/content.aspx?aid=1178762302
RD 2024/04/25
AB Drug  addiction  is  a  chronic  disease  that  is  characterized  by  loss  of  control,  cravings,  and  compulsive  use  despite  negative  consequences.  As  a  neuropsychiatric  disease,  addiction  is  conceptualized  as  a  cycle  of  binge/intoxication,  withdrawal/negative  affect,  and  preoccupation/anticipation.  The  stages  of  the  cycle  are  directed  by  activity  and  neuroadaptations  that  occur  at  different  regions  of  the  brain  with  repeated  drug  use.  As  reviewed  in  this  chapter,  key  structures  involved  in  each  of  these  stages  include  the  ventral  tegmental  area  (VTA)  in  binge/intoxication,  extended  amygdala  (including  the  bed  of  stria  terminalis,  nucleus  accumbens,  and  amygdala)  in  withdrawal/negative  affect  and  craving,  and  orbitofrontal  cortex,  basolateral  amygdala,  and  hippocampus  in  preoccupation/anticipation.1