RT Book, Section
A1 Dickerson, Bradford C.
A1 Quimby, Megan
A1 Brandt, Katherine
A1 Lucente, Diane E.
A1 Wong, Bonnie
A2 Silbersweig, David A.
A2 Safar, Laura T.
A2 Daffner, Kirk R.
SR Print(0)
ID 1178763543
T1 Frontotemporal Dementia
T2 Neuropsychiatry and Behavioral Neurology: Principles and Practice
YR 2021
FD 2021
PB McGraw Hill
PP New York, NY
SN 9781260117103
LK neurology.mhmedical.com/content.aspx?aid=1178763543
RD 2024/04/25
AB Professor  Arnold  Pick  first  reported,  in  1892,  a  71-year-old  patient  with  progressive  language  and  cognitive  decline,  and  grossly  visible  anterior  temporal  lobe  atrophy  post-mortem.1  This  is  thought  to  be  the  first  report  of  a  patient  with  what  was  later  called  semantic  dementia  by  Professors  John  Hodges  and  Julie  Snowden.  Professor  Alois  Alzheimer  subsequently  described  the  microscopic  histologic  abnormalities  that  were  later  called  “Pick’s  disease”  by  Drs.  Onari  and  Spatz.  Professor  Schneider  published  a  detailed  report  on  clinical  course  of  the  disease,  highlighting  the  insidious  early  changes  in  behavior  and  personality  and—in  contrast  with  Alzheimer’s  disease  (AD)—the  typical  relative  preservation  of  memory  and  orientation.2  Through  most  of  the  rest  of  the  century,  patients  with  behavioral-comportmental  dementias  were  usually  diagnosed  as  having  “Pick’s  disease.”  In  the  1980s  and  1990s,  Professors  Marsel  Mesulam,  Sandra  Weintraub,  John  Hodges,  Julie  Snowden,  Andrew  Kertesz,  and  others  reignited  the  interest  of  the  behavioral  neurology  and  neuropsychiatry  field  in  progressive  aphasias.3–5  In  the  1980s,  the  Lund6  and  Manchester7  groups  reported  important  early  studies  generating  renewed  interest  in  the  behavioral  phenotype  of  frontotemporal  dementia  (FTD),  soon  thereafter  proposing  clinical  and  pathological  diagnostic  criteria.8  In  the  late  1990s,  formal  international  consensus  diagnostic  criteria9  were  developed  for  three  major  clinical  phenotypes:  “frontotemporal  dementia,”  “progressive  nonfluent  aphasia,”  and  “semantic  dementia.”  In  the  early  2000s,  interest  in  the  syndromes  we  now  call  FTDs  surged,  leading  to  the  development  and  evolution  of  clinical  and  pathological  criteria  for  the  diagnosis  and,  more  recently,  an  explosion  in  scientific  understanding  of  this  family  of  diseases,  as  well  as  a  robust  international  clinical-scientific  organization  devoted  to  the  diseases  (http://www.isftd.org)  with  biannual  international  conferences  sparking  tremendous  collaborative  energy.10  Important  advances  were  formalized  in  2011  when  new  consensus  diagnostic  criteria  were  published  for  primary  progressive  aphasia  (PPA)11  and  the  behavioral  variant  of  FTD  (bvFTD).12  These  criteria  were  then  largely  incorporated  with  some  simplification  into  the  fifth  edition  of  the  American  Psychiatric  Association  Diagnostic  and  Statistical  Manual  in  2013.