RT Book, Section
A1 Kandel, Eric R.
A1 Koester, John D.
A1 Mack, Sarah H.
A1 Siegelbaum, Steven A.
SR Print(0)
ID 1180640844
T1 Modulation of Synaptic Transmission and Neuronal Excitability: Second Messengers
T2 Principles of Neural Science, 6e
YR 2021
FD 2021
PB McGraw Hill
PP New York, NY
SN 9781259642234
LK neurology.mhmedical.com/content.aspx?aid=1180640844
RD 2024/04/19
AB THE  BINDING  OF  NEUROTRANSMITTER  to  postsynaptic  receptors  produces  a  postsynaptic  potential  either  directly,  by  opening  ion  channels,  or  indirectly,  by  altering  ion  channel  activity  through  changes  in  the  postsynaptic  cell’s  biochemical  state.  As  we  saw  in  Chapters  11  to  13,  the  type  of  postsynaptic  action  depends  on  the  type  of  receptor.  Activation  of  an  ionotropic  receptor  directly  opens  an  ion  channel  that  is  part  of  the  receptor  macromolecule  itself.  In  contrast,  activation  of  metabotropic  receptors  regulates  the  opening  of  ion  channels  indirectly  through  biochemical  signaling  pathways;  the  metabotropic  receptor  and  the  ion  channels  regulated  by  the  receptor  are  distinct  macromolecules  (Figure  14–1).