RT Book, Section A1 Kandel, Eric R. A1 Koester, John D. A1 Mack, Sarah H. A1 Siegelbaum, Steven A. SR Print(0) ID 1180641687 T1 Pain T2 Principles of Neural Science, 6e YR 2021 FD 2021 PB McGraw Hill PP New York, NY SN 9781259642234 LK neurology.mhmedical.com/content.aspx?aid=1180641687 RD 2024/04/24 AB ACCORDING TO THE INTERNATIONAL ASSOCIATION for the Study of Pain, pain is an unpleasant sensation and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Pricking, burning, aching, stinging, and soreness are among the most distinctive of all the sensory modalities. As with the other somatosensory modalities—touch, pressure, and position sense—pain serves an important protective function, alerting us to injuries that require evasion or treatment. In children born with insensitivity to pain, severe injuries often go unnoticed and can lead to permanent tissue damage. Yet pain is unlike other somatosensory modalities, or vision, hearing, and smell, in that it has an urgent and primitive quality, possessing a powerful emotional component.