RT Book, Section A1 Watts, Lora Talley A1 Jaramillo, Carlos A. A1 Eapen, Blessen C. A2 Mitra, Raj SR Print(0) ID 1182776795 T1 The Pathophysiology of Traumatic Brain Injury T2 Principles of Rehabilitation Medicine YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9780071793339 LK neurology.mhmedical.com/content.aspx?aid=1182776795 RD 2024/03/28 AB Traumatic brain injury (tbi) is classically defined as an insult to the brain caused by an external physical force with a resulting alteration in brain function. The insult can be the result of blunt trauma, penetrating, acceleration-deceleration, or blast wave injuries. The result of such an impact varies highly from patient to patient and has been correlated with the severity of injury.1 TBI is considered a leading cause of death and long-term disability worldwide and affects all age groups and genders; however, children and the elderly are often considered at a higher risk of experiencing a TBI.2 Despite the tremendous effort invested in TBI research, the ability to minimize chronic neurologic deficits in TBI patients has remained extremely limited. This is likely a result of the vast complexity of the pathophysiology of a TBI. In fact, it is necessary to continue to explore and understand the underlying mechanisms of a TBI and how these mechanisms relate to functional outcomes.