RT Book, Section
A1 Williams, Lisa M.
A1 Fini, Habib Mofakham
A1 Joyce, Nanette C.
A2 Mitra, Raj
SR Print(0)
ID 1182782688
T1 Neuromuscular Disease: Motor Neuron Disorders
T2 Principles of Rehabilitation Medicine
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071793339
LK neurology.mhmedical.com/content.aspx?aid=1182782688
RD 2024/04/24
AB Motor  neuron  diseases  (mnds)  are  a  heterogeneous  group  of  neurologic  conditions  characterized  by  corticospinal  tract  and  anterior  horn  cell  degeneration  of  the  brain  and  spinal  cord1  (Fig.  71–1).  While  the  etiology  of  MNDs  is  broad  and  not  clearly  elucidated,  there  is  evidence  supporting  multifactorial  processes  that  can  be  inherited  genetically  or  acquired  sporadically  through  environmental  exposures  such  as  toxins,  infections,  and  autoimmune  or  other  causes.2–8  The  common  pathology  is  the  destruction  of  motor  neurons  and  encompasses  disorders  with  selective  loss  of  lower  motor  neurons  (LMNs),  upper  motor  neurons  (UMNs),  or  a  combination  of  both.2  This  results  in  muscle  weakness  and  disability  with  loss  of  normal  limb,  speech,  swallow,  and  respiratory  functions.