RT Book, Section
A1 Kandel, Eric R.
A1 Koester, John D.
A1 Mack, Sarah H.
A1 Siegelbaum, Steven A.
SR Print(0)
ID 1192998911
T1 Differentiation and Survival of Nerve Cells
T2 Principles of Neural Science, 6e
YR 2021
FD 2021
PB McGraw Hill
PP New York, NY
SN 9781259642234
LK neurology.mhmedical.com/content.aspx?aid=1192998911
RD 2024/04/20
AB IN  THE  PRECEDING  CHAPTER,  WE  DESCRIBED  how  local  inductive  signals  pattern  the  neural  tube  and  establish  the  early  regional  subdivisions  of  the  nervous  system—the  spinal  cord,  hindbrain,  midbrain,  and  forebrain.  Here,  we  turn  to  the  issue  of  how  progenitor  cells  within  these  regions  differentiate  into  neurons  and  glial  cells,  the  two  major  cell  types  of  the  nervous  system.  The  mature  brain  comprises  billions  of  nerve  cells  and  a  similar  number  of  glial  cells  arranged  in  complex  patterns,  yet  its  precursor,  the  neural  plate,  initially  contains  only  a  few  hundred  cells  arranged  in  a  simple  columnar  epithelium.  From  this  observation  alone,  it  should  be  apparent  that  the  generation  of  neural  cells  and  their  delivery  to  appropriate  sites  must  be  carefully  regulated.