RT Book, Section
A1 West, Andrew B.
A2 Watts, Ray L.
A2 Standaert, David G.
A2 Obeso, Jose A.
SR Print(0)
ID 55792363
T1 Chapter 9. Genetics of Parkinson's Disease and Parkinsonian Disorders
T2 Movement Disorders, 3e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-161312-5
LK neurology.mhmedical.com/content.aspx?aid=55792363
RD 2024/04/19
AB Parkinson's  disease  (PD)  is  the  second  most  common  neurodegenerative  disease,  with  some  estimates  suggesting  over  one  million  Americans  suffering  with  symptoms.  The  pathological  hallmark  of  PD  that  gives  rise  to  the  trademark  motor  complications  is  the  loss  of  melanized  tyrosine-hydroxylase-positive  dopaminergic  neurons  in  the  substantia  nigra  pars  compacta.  The  fundamental  mechanisms  underlying  the  loss  of  this  indispensable  nucleus  of  neurons  remain  largely  a  mystery.  Additional  lesions  and  cell  loss  likewise  occur  in  many  regions  throughout  the  central  and  peripheral  nervous  system,  probably  responsible  for  the  diverse  and  debilitating  non-motor  symptoms  associated  with  the  disease.1,  2